4-Chlorobenzoic Acid → HCID 22103776, compound

Participants

Reaction Steps

To 2'-[(methylamino)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide (24.1 mg, 0.055 mmol, prepared as described in Step (A) of Example 28) and 4-chlorobenzoic acid (7.8 mg, 0.05 mmol) in 0.5 ml of CH2Cl2, 4-dimethylaminopyridine (6.7 mg, 0.055 mmol) was added and followed by 1,3-diisopropylcarbodiimide (6.9 mg, 0.055 mmol). The reaction was stirred at room temperature for 18 hrs and concentrated. The residue was dissolved in MeOH, neutralized to pH>8 with aq. NaHCO3, and filtered. The filtrate was acidified to pH<5 with NaHSO4, and filtered to provide the title compound of this Example (18 mg, 62%) as a white solid, m.p. 122°-132° C. (amorphous).

Provenance & Evidence