反应详情

(2R,3S)-3-(4-Methoxyphenyl)-2,3-epoxypropionic acid methyl ester (10.4 g) is mixed with 15.3 wt % solution of ammonia in methanol (56 g), and the mixture is reacted at 15° C. for 2.5 hours. The mixture is concentrated under reduced pressure until the total weight of the mixture becomes 44 g. To the mixture is added ice-water (112 g), and the mixture is stirred for two hours under ice-cooling. The precipitated crystals are collected by filtration, washed with water, and dried at 50° C. to give (2R,3S)-3-(4-methoxyphenyl)-2,3-epoxypropionamide (8.99 g).

1. customthe mixture is reacted at 15° C. for 2.5 hours
2. concentrationThe mixture is concentrated under reduced pressure until the total weight of the mixture
3. additionTo the mixture is added ice-water (112 g)
4. temperaturecooling
5. filtrationThe precipitated crystals are collected by filtration
6. washwashed with water
7. customdried at 50° C.