Sodium Hydroxide → HCID 22104540, compound

Participants

Reaction Conditions

Reaction Steps

1-[2-(3,4-Dihydro-7-methoxycarbonyl-2-naphthalenyl)ethyl]pyrrolidine (1.0 g) was dissolved in ethanol (5 ml), and thereto was added 1N aqueous sodium hydroxide solution (5.2 ml), and the mixture was stirred at 25° C. for 6 hours. The mixture was concentrated under reduced pressure to remove the solvent, and the residue was acidified with 10% hydrochloric acid. The precipitated crystals were collected by filtration, and subjected to desalting with using CHP-20P [manufactured by Mitsubishi Kasei Corporation, high porous polystyrene resin; 75-150 μm] (eluent; water, then acetonitrile). The eluents were concentrated under reduced pressure, and the residue was recrystallized from ethanol-ethyl methyl ketone to give the desired compound, m.p. 202°-203° C.

Provenance & Evidence