HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1457324Generated: November 1, 2026
Phosphoric Acid → (5-fluoro-3,4-dihydro-1-oxo-2(1H)-naphthalenylidene)acetic acid
https://huagongshe.com/reaction/1457324
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphoric Acid | HCID 1004 | — |
| Reactant | 5-Fluoro-1,2,3,4-tetrahydronaphthalen-1-one | HCID 15491038 | — |
| Reactant | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| Solvent | Water | HCID 962 | — |
| Product | (5-fluoro-3,4-dihydro-1-oxo-2(1H)-naphthalenylidene)acetic acid | HCID 53647021 | 96.9% |
Reaction Steps
A mixture of 5-fluoro-3,4-dihydro-1(2H)-naphthalenone (10 g), glyoxylic acid monohydrate (6.2 g) and 85% phosphoric acid (10 ml) was stirred at 90° C. for three hours. After cooling, water was added to the reaction solution, and the precipitated crystals were collected by filtration, washed with water, and dried to give (5-fluoro-3,4-dihydro-1-oxo-2(1H)-naphthalenylidene)acetic acid (13 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05847159 |
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| Source dataset | uspto-grants-1998_12 |
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| ORD ID | ord-6e3cb22961d74446ab5cf94ced52ef73 |
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| Source note | uspto-grants-1998_12 |
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