Dimethyl Sulfoxide → HCID 22104461, compound

Participants

Reaction Steps

1.1 g (3.1 mmol) of the title compound of Example 4 was oxidized as described in Example 2 using 1.1 ml (15 mmol) DMSO, 1.9 ml (12.4 mmol) TFAA, 2.2 ml (16 mmol) triethylamine in 25 ml methylene chloride. The crude product was chromatographed on silica gel with chloroform as the eluant to yield 0.3 g of material which was triturated with hot diisopropyl ether to yield 10 mg (1%) crystalline title product. 1H NMR (CDCl3) δ: 9.60(s); 9.30(s,1H); 7.15-7.60(m,10H); 4.10-5.20(m,8H). High Resolution Mass Spectrum: 326.1147±5.8 ppm (C18H18N2O2S).

Provenance & Evidence