反应详情

1.57 g (10.3 mmol) of 4-methoxyphenyl malonic acid, 3.0 g (10.3 mmol) of 2-(4-bromophenyl) ethylbenzylether, 0.38 g of tetrakis (triphenylphosphine) palladium, 15 ml of 2M-sodium carbonate solution, 15 ml of toluene and 10 ml of ethanol were heated at 80° C. for 4 hours under presence of nitrogen. After reactions had been completed, extraction with toluene was performed. Then, the extracted solution was dried with anhydrous sodium sulfate. The solvent was removed by filtration, and then refining was performed with a silica gel column chromatography (developing solvent: toluene) and by recrystallization (ethanol) so that 2.63 g of 2-{4-(4-methoxyphenyl) phenyl}ethylbenzylether was obtained (yield 80%).

1. extractionextraction with toluene
2. dry with materialThen, the extracted solution was dried with anhydrous sodium sulfate
3. customThe solvent was removed by filtration
4. customrefining was performed with a silica gel column chromatography (developing solvent: toluene) and by recrystallization (ethanol) so that 2.63 g of 2-{4-(4-methoxyphenyl) phenyl}ethylbenzylether
5. customwas obtained (yield 80%)