참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Boronic acid, [4-[2-(phenylmethoxy)ethyl]phenyl]- | HCID 11543402 | — |
| 반응물 | 2-Chloro-5-decylpyrimidine | HCID 22099083 | — |
| 촉매 | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | HCID 53830912 | HCID 53830912 | 77% |
반응 단계
1.27 g (4.96 mmol) of 4-(2-benzyloxyethyl) phenylboronic acid, 1.26 g (4.96 mmol) of 2-chloro-5-decylpyrimidine, 0.19 g of tetrakis (triphenylphosphine) palladium, 8 ml of 2M sodium carbonate, 8 ml of toluene and 4 ml of ethanol were, under presence of nitrogen, heated at 80° C. for 3 hours. After the reactions had been completed, extraction with toluene was performed and the extracted solution was dried with anhydrous sodium sulfate. The solvent was removed by filtration and refining was performed by recrystallization (toluene/methanol) so that 1.65 g of 2-{4-(5-decylpyrimidine-2-yl) phenyl}ethylbenzylether was obtained (yield 77%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05849217 |
|---|
| 출처 데이터셋 | uspto-grants-1998_12 |
|---|
| ORD ID | ord-afa26fdf9be64102840a4946620d1a7e |
|---|
| 출처 메모 | uspto-grants-1998_12 |
|---|
