Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | HCID 22097155 | HCID 22097155 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22097136 | HCID 22097136 | 94.7% |
Reaction Steps
52.95 g (0.2 mol) of 7-amino-1-(ethoxycarbonylmethyl)quinoxaline-2,3(1H,4H)-dione and a spatula tip of 4-(N,N-dimethyl-amino)pyridine were suspended in a mixture of 500 ml of glacial acetic acid and 300 ml of tetrahydrofuran and heated to 50° C. Then 20.5 g (0.2 mol) of acetic anhydride were added dropwise, and the mixture was heated at 50° C. for 2 h. The precipitate was filtered off with suction. 57.8 g (94%) of the product were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05849743 |
|---|
| Source dataset | uspto-grants-1998_12 |
|---|
| ORD ID | ord-e8e98428e876403591c75c46e0fdf5e7 |
|---|
| Source note | uspto-grants-1998_12 |
|---|
