HCID 86753430, compound → HCID 86753429, compound

Participants

Reaction Steps

10% Palladium-carbon (Pd-C) (150 mg) was added to 10 ml of a methanol solution containing 500 mg of 2-[3-((1S)-5-benzyloxycarbonylamino-1-methoxycarbonylpentyl)ureido]-4-methoxy-6-tert-butylphenol. The mixture was subjected to catalytic reduction at normal pressure for 2 hours. After removing the catalyst, the reaction mixture was condensed. Methanol was added to the precipitated crystals and the crystals were collected by filtration to give 145 mg of 2-[3-((3S)-2-oxo-perhydroazepin-3-yl)ureido]-4-methoxy-6-tert-butylphenol (yield: 43%, melting point: 178°-179° C.).

Provenance & Evidence