Methane → HCID 22099489, compound

Participants

Reaction Steps

To a mixture of 680 mg of 2-{[4-(4-nitrophenyl)piperazin-1-yl]carbonylamino}-4-methoxy-6-tert-butylphenol hydrochloride, 30 ml of methanol and 30 ml of dioxane was added 100 mg of 10% palladium-carbon (Pd-C). The mixture was subjected to catalytic reduction for 4 hours by using a Parr's reduction apparatus. After removing the catalyst by filtration, the filtrate was condensed. The residue was dissolved in 10 ml of dichloromethane, and after adding 1 ml of 4N hydrogen chloride-dioxane solution, the mixture was treated with an activated charcoal. The treated mixture was evaporated to dryness under reduced pressure to give 210 mg of 2-{[4-(4-aminophenyl)piperazin-1-yl]carbonylamino}-4-methoxy-6-tert-butylphenol dihydrochloride as powder.

Provenance & Evidence