HCID 22099599, compound → HCID 135719546, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1.0 g of 1,4,5,6-tetrahydro-6-[(2-methylphenyl)sulfonyl]pyrazolo[4,3-d][1]benzazepine in 60 ml of 40% (V/v)H2SO4 in glacial acetic acid is heated at 60° C. for 12 hours or until the tosyl group is removed. The mixture is poured into 100 ml ice and water with cooling. Solid NaOH is added portionwise (temperature kept below 30° C.) with efficient stirring and the pH brought to 8. The mixture is extracted with ethyl acetate and the extract dried (Na2SO4) and the solvent removed to give a solid.

Provenance & Evidence