Hexane → 4-[([1,1′-Biphenyl]-2-ylcarbonyl)amino]-3-methoxybenzoyl chloride

HRID 1457657Notes

Reaction equation

HRID 1457657 reaction equation
[C:1]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:2]([C:7]([NH:9][C:10]2[CH:18]=[CH:17][C:13]([C:14](O)=[O:15])=[CH:12][C:11]=2[O:19][CH3:20])=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1.CCCCCC.S(Cl)([Cl:35])=O>>[C:1]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:2]([C:7]([NH:9][C:10]2[CH:18]=[CH:17][C:13]([C:14]([Cl:35])=[O:15])=[CH:12][C:11]=2[O:19][CH3:20])=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 8058HexaneHCID 24386Thionyl ChlorideHCID 69550140HCID 69550140, compound

Product 1

HCID 220996544-[([1,1′-Biphenyl]-2-ylcarbonyl)amino]-3-methoxybenzoyl chloride

Procedure

A solution of 2.69 g of 4-[([1,1'-biphenyl]-2-carbonyl]amino]-3-methoxy benzoic acid in 5 ml of thionyl chloride is heated on a steam bath for 1 hour under Argon. The volatiles are removed in vacuo to give a residue which is stirred with hexane to give 2.58 g of crystalline solid, m.p. 121°-123° C. M+=361.

Workup

  1. customThe volatiles are removed in vacuo
  2. customto give a residue which

Sources & evidence

ORD record
ord-6b6b5a8c487d4df2b8281a54cf560535
Source dataset
uspto-grants-1998_12
Patent number
US05849735

Reaction notes

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