HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[5-(Pyrido[2,3-b][1,4]benzoxazepin-5(6H)-ylcarbonyl)-2-pyridinyl]-5-fluoro-2-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6-(5-Fluoro-2-methylbenzoyl)aminopyridine-3-carbonyl chloride | HCID 15508250 | — |
| Reactant | 5,6-Dihydropyrido[2,3-b][1,4]benzoxazepine | HCID 22099816 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[5-(Pyrido[2,3-b][1,4]benzoxazepin-5(6H)-ylcarbonyl)-2-pyridinyl]-5-fluoro-2-methylbenzamide | HCID 22099717 | — |
Reaction Steps
As described for Example 1, 5,6-dihydropyrido[2,3-b][1,4]benzoxazepine is reacted in dichloromethane, in the presence of triethylamine, with 6-[(5-fluoro-2-methylbenzoyl)amino]pyridine-3-carbonyl chloride to give the product as white crystals, m.p. 187°-189° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05849735 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-68e529516a6d476db196d139257fa837 |
| Source note | uspto-grants-1998_12 |