Sodium Hydroxide → HCID 22099898, compound

HRID 1457690Notes

Reaction equation

HRID 1457690 reaction equation
[NH:1]1[C:10]2[C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[NH:7][CH2:6][CH2:5][C:4]=2[CH:3]=[N:2]1.[C:15]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:20]=[CH:19][C:18]([C:21](Cl)=[O:22])=[CH:17][CH:16]=1.[OH-].[Na+]>CO>[C:15]1([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:16]=[CH:17][C:18]([C:21]([N:7]2[C:8]3[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=3[C:10]3[NH:1][N:2]=[CH:3][C:4]=3[CH2:5][CH2:6]2)=[O:22])=[CH:19][CH:20]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 841514-Phenylbenzoyl chlorideHCID 135719546HCID 135719546, compound

Product 1

HCID 22099898HCID 22099898, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

As described for Example 26, 2 mmol of 1,4,5,6-tetrahydropyrazolo[4,3-d][1]benzazepine is reacted with 5 mmol of [1,1'-biphenyl]-4-carbonyl chloride. The product is stirred in methanol with 2N NaOH for 16 hours and the mixture concentrated and extracted with ethyl acetate. The extract is washed with 1M citric acid, NaHCO3, H2O, dried (Na2SO4) and the solvent removed to give the product of the example as a solid.

Workup

  1. concentrationthe mixture concentrated
  2. extractionextracted with ethyl acetate
  3. washThe extract is washed with 1M citric acid, NaHCO3, H2O
  4. dry with materialdried (Na2SO4)
  5. customthe solvent removed
  6. customto give the product of the example as a solid

Sources & evidence

ORD record
ord-f2c2c5acc167458b8e31794ba5fd8aec
Source dataset
uspto-grants-1998_12
Patent number
US05849735

Reaction notes

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