HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → N-[5-(Pyrido[2,3-b][1,4]benzoxazepin-5(6H)-ylcarbonyl)-2-pyridinyl]-5-fluoro-2-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 6-(5-Fluoro-2-methylbenzoyl)aminopyridine-3-carbonyl chloride | HCID 15508250 | — |
| Reactant | 5,6-Dihydropyrido[2,3-b][1,4]benzoxazepine | HCID 22099816 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[5-(Pyrido[2,3-b][1,4]benzoxazepin-5(6H)-ylcarbonyl)-2-pyridinyl]-5-fluoro-2-methylbenzamide | HCID 22099717 | — |
Reaction Steps
As described for Example 46, the reaction of 5,6-dihydropyrido[2,3-b][1,4]benzoxazepine (1 mmol) with 2-[(2-methyl-5-fluorobenzoyl)amino]-5-pyridinylcarbonyl chloride (1.0 mmol) in dichloromethane in the presence of N,N-diisopropylethylamine (3 mmol) gives the product as a glass.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05849735 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-70c900c30b134f2a8f9bae511aec47c3 |
| Source note | uspto-grants-1998_12 |