6-[([1,1'-Biphenyl]-2-ylcarbonyl)amino]-3-pyridinecarbonyl chloride → HCID 22099578, compound

HRID 1457703Notes

Reaction equation

HRID 1457703 reaction equation
[N:1]1[C:10]2[C:4]([CH2:5][CH2:6][N:7]=[C:8]3[CH:14]=[CH:13][CH:12]=[CH:11][C:9]3=2)=[CH:3][N:2]=1.[C:15]1([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[C:16]([C:21]([NH:23][C:24]2[N:29]=[CH:28][C:27]([C:30](Cl)=[O:31])=[CH:26][CH:25]=2)=[O:22])=[CH:17][CH:18]=[CH:19][CH:20]=1>>[NH:1]1[C:10]2[C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[N:7]([C:30]([C:27]3[CH:26]=[CH:25][C:24]([NH:23][C:21]([C:16]4[C:15]([C:33]5[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=5)=[CH:20][CH:19]=[CH:18][CH:17]=4)=[O:22])=[N:29][CH:28]=3)=[O:31])[CH2:6][CH2:5][C:4]=2[CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 220997926-[([1,1'-Biphenyl]-2-ylcarbonyl)amino]-3-pyridinecarbonyl chlorideHCID 22099958HCID 22099958, compound

Product 1

HCID 22099578HCID 22099578, compound

Procedure

As described for Example 396, (0.1 mmol) of 4,5-dihydropyrazolo[4,3-d][1]benzazepine is reacted with (0.21 mmol) of 6-[([1,1'-biphenyl]-2-carbonyl)amino]pyridine-3-carbonyl chloride to give the product as a light tan solid. Recrystallized from ethyl acetate/hexane, m.p. 228° C.-234° C. as white crystals.

Sources & evidence

ORD record
ord-2b9c1bdf49ba4839bd19320f3a458367
Source dataset
uspto-grants-1998_12
Patent number
US05849735

Reaction notes

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