HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl malonate → 4(3H)-Pyrimidinone, 6-hydroxy-2-[4-(trifluoromethyl)phenyl]-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl malonate | HCID 7943 | — |
| Reactant | 4-(Trifluoromethyl)benzamidine Hydrochloride | HCID 12535791 | — |
| Reactant | Potassium methoxide | HCID 23664618 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4(3H)-Pyrimidinone, 6-hydroxy-2-[4-(trifluoromethyl)phenyl]- | HCID 15477092 | — |
Reaction Steps
4-Trifluormethylbenzamidine hydrochloride (22.4 g, 0.1 mol, from example 41) is added to a solution of potassium methylate (0.22 mol) in anhydrous methyl alcohol (65 mL) and stirred for 15 minutes at ambient temperature. Dimethyl malonate (12.6 mL, 0.11 mol) is added and the mixture is heated to reflux for 4 hours. After cooling, the resulting suspension is diluted with methyl alcohol (50 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05849758 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-a5b8139e7d7b4fdeafcfaf9f45d25873 |
| Source note | uspto-grants-1998_12 |