Methane → 3-(5-Fluoro-2-methoxybenzamido)-6-(methylaminothiocarbonylaminosulfonyl)-7-methoxychroman

Participants

Reaction Conditions

Reaction Steps

1.65 g (12 mmol) of powdered potassium carbonate and 0.35 g (4.8 mmol) of methyl isothiocyanate were added to 1.64 g (4 mmol) of 3-(5-fluoro-2-methoxybenzamido)-6-sulfamoyl-7-methoxychroman (Example 9) in 10 ml of dry DMSO. After the mixture had been stirred at 80° C. for 25 minutes, it was cooled, introduced into ice-water, clarified with charcoal and acidified to pH 1. The precipitate was filtered off with suction, dried and recrystallized from ethanol. The product had a melting point of 221°-222° C.

Provenance & Evidence