Methane → HCID 15872194, compound

Participants

Reaction Conditions

Reaction Steps

1.64 g (4 mmol) of 3-(5-chloro-2-methoxybenzamido)-6-sulfamoyl-7-methylchroman were dissolved in 10 ml of dry DMSO, and 1.65 g (12 mmol) of finely powdered potassium carbonate and 0.35 g (4.8 mmol) of methyl isothiocyanate were added. After the mixture had been stirred at 80° C. for 25 minutes, it was cooled, introduced into ice-water, clarified with charcoal and acidified to pH 1. The precipitate was filtered off with suction, dried, purified over a silica gel column using ethyl acetate/toluene 2:1 and recrystallized from ethanol. Melting point: 207°-208° C.

Provenance & Evidence