5-Chloro-2-methoxybenzoyl chloride → HCID 22100465, compound

Participants

Reaction Steps

17.5 g (85 mmol) of 5-chloro-2-methoxybenzoyl chloride were added to a solution of 18.2 g (85 mmol) of 3-amino-7-methyl-4-chromanone hydrochloride (Hebd. Seances Acad. Sci. Ser. C. 279, 281-284) in 90 ml of pyridine at room temperature. After the mixture had been stirred for 2 hours (TLC control: silica gel plate using petroleum ether/ethyl acetate/toluene 2:2:1), it was introduced into ice/water. The precipitate was filtered off with suction, washed several times with water and dried. The 3-(5-chloro-2-methoxybenzamido)-7-methyl-4-chromanone had a melting point of 177°-178° C.

Provenance & Evidence