Hydrochloric Acid → HCID 22100464, compound

Participants

Reaction Steps

0.5 g (12.5 mmol) of sodium borohydride was introduced into a suspension of 8.65 g (25 mmol) of 3-(5-chloro-2-methoxybenzamido)-7-methyl-4-chromanone in 40 ml of ethanol. During stirring at 30°-40° C. for 2 hours, the solid dissolved. The solution was then cooled, introduced into ice/water and acidified to pH 1-2 with dilute hydrochloric acid. The precipitate was filtered off with suction, washed with water, dried and recrystallized from ethanol. The resulting 3-(5-chloro-2-methoxybenzamido)-7-methylchroman-4-ol (diastereomer mixture) had a melting point of 151°-152° C.

Provenance & Evidence