HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1457755Generated: October 27, 2026
Methane → 3-(5-Chloro-2-methoxybenzamido)-2,2-dimethyl-6-(methylaminocarbonylaminosulfonyl)-7-methoxychroman
https://huagongshe.com/reaction/1457755
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methane | HCID 297 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2,2,2-Trichloro-n-methylacetamide | HCID 248652 | — |
| Reactant | 3-(5-Chloro-2-methoxybenzamido)-2,2-dimethyl-6-sulfamoyl-7-methoxychroman | HCID 22100441 | — |
| Product | 3-(5-Chloro-2-methoxybenzamido)-2,2-dimethyl-6-(methylaminocarbonylaminosulfonyl)-7-methoxychroman | HCID 22100470 | — |
Reaction Steps
1.23 g (7.5 mmol) of N-methyltrichloroacetamide were added to 2.27 g (5 mmol) of 3-(5-chloro-2-methoxybenzamido)-2,2-dimethyl-6-sulfamoyl-7-methoxychroman and 0.5 g (12.5 mmol) of finely powdered sodium hydroxide. After the mixture had been stirred at 80° C. for half an hour, it was introduced into ice/water, clarified with charcoal and acidified to pH 1. The precipitate was filtered off with suction, dried and recrystallized from ethanol/DMF. The product had a melting point of 248° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05849755 |
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| Source dataset | uspto-grants-1998_12 |
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| ORD ID | ord-16eecf5dd5c2493bb7c0041507458fe4 |
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| Source note | uspto-grants-1998_12 |
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