4-Toluenesulfonyl chloride → HCID 86753437, compound

Participants

Reaction Steps

85.8 g (0.45 mol) of p-toluenesulfonyl chloride were introduced into a solution of 88.5 g (0.4 mol) of 2,2-dimethyl-7-methoxy-4-chromanone oxime (Heterocycles 38 (1994), 305-318) in 550 ml of pyridine at 0° C. The mixture was allowed to come to room temperature and was subsequently stirred for several hours, stirred into ice/water and extracted with methylene chloride. The organic solution was washed twice with 2N hydrochloric acid and then several times with water, dried and evaporated, and the residue was recrystallized from ethanol. The 2,2-dimethyl-7-methoxy-4-chromanone oxime tosylate had a melting point of 113° C.

Provenance & Evidence