Methane → 3-(5-Chloro-2-methoxybenzamido)-2,2-dimethyl-6-(methylaminothiocarbonylaminosulfonyl)-7-methoxychroman

Participants

Reaction Conditions

Reaction Steps

0.26 g (3.5 mmol) of methyl isothiocyanate was added to a suspension of 1.14 g (2.5 mmol) of 3-(5-chloro-2-methoxybenzamido)-2,2-dimethyl-6-sulfamoyl-7-methoxychroman and 1.04 g (7.5 mmol) of finely powdered potassium carbonate in 10 ml of DMSO. After the mixture had been stirred at 80° C. for 25 minutes, it was cooled, introduced into ice/water, clarified with charcoal and acidified to pH 1. The precipitate was filtered off with suction and recrystallized from methanol/DMF. The product had a melting point of 234°-235° C.

Provenance & Evidence