HCID 22100428, compound → HCID 22100456, compound

HRID 1457762Notes

Reaction equation

HRID 1457762 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:26][CH3:27])=[C:6]([CH:25]=1)[C:7]([NH:9][CH:10]1[CH:19](O)[C:18]2[C:13](=[CH:14][C:15]([O:21][CH3:22])=[CH:16][CH:17]=2)[O:12][C:11]1([CH3:24])[CH3:23])=[O:8]>C(Cl)Cl.C(OCC)(=O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:26][CH3:27])=[C:6]([CH:25]=1)[C:7]([NH:9][CH:10]1[CH2:19][C:18]2[C:13](=[CH:14][C:15]([O:21][CH3:22])=[CH:16][CH:17]=2)[O:12][C:11]1([CH3:23])[CH3:24])=[O:8]

Participants

3

Reactant 1

HCID 22100428HCID 22100428, compound

Product 1

HCID 22100456HCID 22100456, compound

Reagents, catalysts & solvents 1

HCID 21226138Dichloromethane ethylacetateSolvent

Procedure

A reduction was carried out analogously to Example 15e using 18.8 g (50 mmol) of 3-(5-fluoro-2-methoxybenzamido)-2,2-dimethyl-7-methoxy-4-chromanol. After chromatography over a silica gel column using methylene chloride/ethyl acetate 95:5, the 3-(5-fluoro-2-methoxybenzamido)-2,2-dimethyl-7-methoxychroman was obtained as an oil.

Sources & evidence

ORD record
ord-f2f03b21e4fa442aaea9c62166e6ef6d
Source dataset
uspto-grants-1998_12
Patent number
US05849755

Reaction notes

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