Hydrogen Peroxide → HCID 22100446, compound

Participants

Reaction Conditions

Reaction Steps

1 g of 3-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)-6-(methylaminothiocarbonylaminosulfonyl)-7-methoxychroman (Example 22) was suspended or dissolved in 20 ml of cold 0.5N sodium hydroxide solution. 1 ml of 37% strength hydrogen peroxide solution was added in the cold (-4° to 0° C.). The mixture was stirred at 0° C. for 1.5 hours. The crude product was precipitated by addition of 2N HCl and then purified over silica gel (eluting agent methylene chloride/glacial acetic acid 9:1). The product had a melting point of 245°-246° C.

Provenance & Evidence