HCID 22100392, compound → HCID 178441435, compound

Participants

Reaction Steps

4 g(0.010 mole) of the compound obtained in step 8 was dissolved in a mixture of 40 ml of acetic acid and 40 ml of methanol and to the resulting solution was added 13.1 g(0.0002 mole) of zinc powder. The resultant was stirred under ultrasonification for 4 hours, filtered and washed with acetic acid(10 ml×3). To the filtrate was added 50 ml of saturated aqueous ethylene diamine tetraacetic acid solution and then the resultant was stirred for 10 minutes. After adding 100 ml of ethyl acetate, the solution was filtered and washed with 100 ml of aqueous 10% NaHCO3 solution. The organic layer was dried over Na2SO4 and concentrated under reduced pressure. The residue was purified with column chromatography(CH2Cl2 → 10% MeOH/CH2Cl2) to obtain 2.4 g of the title compound(yield 86%).

Provenance & Evidence