HCID 22100363, compound → HCID 22100408, compound

Participants

Reaction Steps

1 g(0.00249 mole) of the compound obtained in step 7 of Example 1 was dissolved in 10 ml of toluene and to the resulting solution were 1 g(0.00274 mole) of 2-tributyltin pyridine and 0.058 g(0.00005 mole) of tetrakistriphenyl-phosphine palladium. The resultant was refluxed for 24 hours, and cooled to room temperature after the completion of the reaction. The reaction solution was extracted with 100 ml of ethyl acetate and washed with 100 ml of water. The organic layer was dried over MgSO4, filtered and concentrated under reduced pressure, and the residue was purified with column chromatography (ethyl acetate) to obtain 0.705 g of the title compound(yield 71%).

Provenance & Evidence