HCID 22100389, compound → HCID 22100372, compound

Participants

Reaction Steps

0.25 g(0.00088 mole) of 6-bromo-2-butyl-5-hydroxymethyl-1H-imidazo[4,5-b]pyridine obtained in step 6 of Example 1 was dissolved in 10 ml of ethanol and to the resulting solution was added 0.03 g of 10% palladium/activated carbon. The resultant was reacted at room temperature for 3 hours under about 3 atm of hydrogen using a hydrogenation apparatus. The reaction solution was filtered through Cellite with washing with 10% methanol/ethyl acetate(10 ml×3) and concentrated under reduced pressure to obtain 0.167 g of the title compound(yield 93%).

Provenance & Evidence