Triethylamine → HCID 70208434, compound

Participants

Reaction Conditions

Reaction Steps

5.08 g(0.0127 mole) of the compound obtained in step 7 of Example 1 was dissolved in 12 ml of dimethylformamide(DMF) and to the resulting solution were added 5.64 g(0.0381 mole) of styrylboric acid, 0.29 g(0.00127 mole) of palladium acetate, 0.67 g(0.00254 mole) of triphenylphosphine and 13 ml(0.0889 mole) of triethylamine. The resultant was stirred for 1 hour at 120° C., cooled, extracted with 300 ml of ethyl acetate and washed with 300 ml of water. The organic layer was dried over anhydrous magnesium sulfate, concentrated under reduced pressure and purified with column chromatography (methanol/methylene chloride=1:9) to obtain 4.58 g of the title compound(yield 85%).

Provenance & Evidence