反应详情

温度

80 °C

To 32.6 g of 40% aqueous methylamine solution was added 7.48 g (0.042 mole) of 2-(3-pyridyl)ethyl chloride hydrochloride in small portions with stirring. The mixture was transfered to a stainless steel reaction column and heated at an external temperature of 80° C. for 4 hours. After cooling, 3.36 g of NaOH was added with ice-cooling and stirring and the mixture was saturated with sodium chloride and extracted with CH2 Cl2. The extract was dried over MgSO4 and the CH2Cl2 was distilled off to give 6.32 g of the title compound in crude form as a yellow oil.

1. temperatureAfter cooling
2. temperaturecooling
3. stirringstirring
4. extractionextracted with CH2 Cl2
5. dry with materialThe extract was dried over MgSO4
6. distillationthe CH2Cl2 was distilled off