Sodium Chloride → N-Methyl-2-(pyridin-3-YL)ethanamine

HRID 1457863Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1457863
[CH3:1][NH2:2].Cl.[N:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][CH2:11]Cl)[CH:5]=1.[OH-].[Na+].[Cl-].[Na+]>>[CH3:1][NH:2][CH2:11][CH2:10][C:6]1[CH:5]=[N:4][CH:9]=[CH:8][CH:7]=1

Komponenten

5

Edukt 4

HCID 5234Sodium ChlorideHCID 6329MethylamineHCID 14798Sodium HydroxideHCID 199465Pyridine, 3-(2-chloroethyl)-, hydrochloride

Produkt 1

HCID 5152594N-Methyl-2-(pyridin-3-YL)ethanamineAusbeute 110,5 %

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To 32.6 g of 40% aqueous methylamine solution was added 7.48 g (0.042 mole) of 2-(3-pyridyl)ethyl chloride hydrochloride in small portions with stirring. The mixture was transfered to a stainless steel reaction column and heated at an external temperature of 80° C. for 4 hours. After cooling, 3.36 g of NaOH was added with ice-cooling and stirring and the mixture was saturated with sodium chloride and extracted with CH2 Cl2. The extract was dried over MgSO4 and the CH2Cl2 was distilled off to give 6.32 g of the title compound in crude form as a yellow oil.

Aufarbeitung

  1. temperatureAfter cooling
  2. temperaturecooling
  3. stirringstirring
  4. extractionextracted with CH2 Cl2
  5. dry with materialThe extract was dried over MgSO4
  6. distillationthe CH2Cl2 was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-446414c8c47a47cf88c9f3bcbcf7d916
Quelldatensatz
uspto-grants-1998_12
Patentnummer
US05849768

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