HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-3-methyl-1-(pyridin-3-ylmethyl)thiourea → 1-(6-Chloro-3-pyridylmethyl)amino-1-dimethylamino-2-nitroethylene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-3-methyl-1-(pyridin-3-ylmethyl)thiourea | HCID 2726729 | — |
| Reactant | 5-(Aminomethyl)-2-chloropyridine | HCID 7020927 | — |
| Reactant | 1-Dimethylamino-1-methylthio-2-nitroethylene | HCID 53896663 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(6-Chloro-3-pyridylmethyl)amino-1-dimethylamino-2-nitroethylene | HCID 59896590 | — |
Reaction Steps
The 1-dimethylamino-1-methylthio-2-nitroethylene (1.0 g) prepared in (1) and 1.0 g of 6-chloro-3-pyridylmethylamine were refluxed in 30 ml of EtOH for 2 hours. The EtOH was then distilled off and the residue was subjected to silica gel column chromatography using CHCl3 -MeOH (10:1) as an eluent. The crystals obtained were recrystallized from EtOH to recover 0.82 g of the title compound as pale yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05849768 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-0275a0bb576b44f1b87505a7f7ff5e17 |
| Source note | uspto-grants-1998_12 |