HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isocyanate → N-(6-chloro-3-pyridyl)-N-ethyl-N'-methylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | 2-Chloro-N-ethylpyridin-5-amine | HCID 22450377 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-(6-chloro-3-pyridyl)-N-ethyl-N'-methylurea | HCID 22450505 | 93.6% |
Reaction Steps
In 30 ml of toluene was dissolved 2.4 g (0.015 mole) of 2-chloro-5-ethylaminopyridine, followed by addition of 3.4 g of methyl isocyanate. The mixture was refluxed for 15 hours. After cooling, the resulting crystals were collected by filtration, washed with a small amount of Et2O and dried. The procedure gave 3.0 g of N-(6-chloro-3-pyridyl)-N-ethyl-N'-methylurea as pale yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05849768 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-fd246a12a33e423c95356369e1f2de68 |
| Source note | uspto-grants-1998_12 |