(2,6-Dichloropyridin-3-YL)methanamine → HCID 22450494、化合物

HRID 1457910ノート

反応式

HRID 1457910 の反応式
Cl[C:2]1C(CN)=CC=C(Cl)N=1.[CH2:11]([N:13]([CH2:18][C:19]1[CH:20]=[N:21][C:22]([F:25])=[CH:23][CH:24]=1)[C:14]([NH:16][CH3:17])=[S:15])[CH3:12].CNC(N(CC)CC1C=NC=CC=1)=S>>[CH3:2][S:15][C:14](=[N:16][CH3:17])[N:13]([CH2:11][CH3:12])[CH2:18][C:19]1[CH:20]=[N:21][C:22]([F:25])=[CH:23][CH:24]=1

参加物

4

反応物 3

HCID 15477284(2,6-Dichloropyridin-3-YL)methanamineHCID 22450434N-methyl-N'-ethyl-N'-(3-pyridylmethyl)thioureaHCID 22450473HCID 22450473、化合物

生成物 1

HCID 22450494HCID 22450494、化合物

実験手順

The reaction procedure of Example 13 (2) was repeated except that N-ethyl-N-(6-fluoro-3-pyridylmethyl)-N'-methylthiourea was used in lieu of N-methyl-N'-ethyl-N'-(3-pyridylmethyl)thiourea to give S-methyl-N-ethyl-N-(6-fluoro-3-pyridylmethyl)-N'-methylisothiourea as a pale brown oil.

出典と根拠

ORDレコード
ord-e8b2d77b30fc494988df083ac1dcbd86
出典データセット
uspto-grants-1998_12
特許番号
US05849768

反応ノート

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