Ethanol → Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate

Participants

Reaction Steps

To a solution of ethyl 3-ethoxy-2-cyanopropenoate (5.14 g) in ethanol (50 ml), was added methylhydrazine (1.61 ml), and the resulted mixture was refluxed for 12 h. The reaction mixture was evaporated under reduced pressure followed by silica-gel column chromatography (chloroform : methanol=50:1) to give 5-amino-4-ethoxycarbonyl-1-methylpyrazole (4.31 g, yield 84%).

Provenance & Evidence