Benzyl Bromide → HCID 22101205, compound

Participants

Reaction Steps

To a solution of 3-amino-1benzyl-4-ethoxycarbonylpyrazole (0.5 g) in DMF (10 ml), was added 60% NaH (0.082 g). After stirring for 5 min at room temperature, benzyl bromide (0.307 ml) was added, and the mixture was stirred for 1 h at room temperature. The reaction mixture was evaporated under reduced pressure followed by silica-gel column chromatography (toluene/ ethyl acetate=50/1) to give 3-benzylamino-1-benzyl-4-ethoxycarbonylpyrazole (0.3 g). This intermediate was derived to the title compound by the similar method to Reference Example 1 (yield 31%).

Provenance & Evidence