Water → HCID 20325024, compound

HRID 1457940Notes

Reaction equation

HRID 1457940 reaction equation
[C:1]([CH2:3][C:4]1[O:5][C:6]2[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=2[CH:8]=1)#N.[OH-:13].[Na+].[OH2:15]>>[C:4]1([CH2:3][C:1]([OH:15])=[O:13])[O:5][CH:6]=[C:12]2[CH:11]=[CH:10][CH:9]=[CH:7][C:8]=12

Participants

4

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 15618732HCID 15618732, compound

Product 1

HCID 20325024HCID 20325024, compound

Conditions

Temperature
25 °C

Procedure

7. The crude cyanomethylbenzofuran, compound 6, was stirred for 6 hours in boiling water (1,000 ml) containing sodium hydroxide (80 g), cooled to 25° C., then washed with methylene chloride (250 ml, then 2×100 ml). The pH was brought to 2.0 with 6N HCl. The precipitate was extracted with methylene chloride (200 ml, then 100 ml, then 50 ml), dried over magnesium sulfate and the solvent evaporated. The yield was approximately 72 g.

Workup

  1. washwashed with methylene chloride (250 ml
  2. extractionThe precipitate was extracted with methylene chloride (200 ml
  3. dry with material100 ml, then 50 ml), dried over magnesium sulfate
  4. customthe solvent evaporated

Sources & evidence

ORD record
ord-2956cc303a5640c0ab6d233eabd1457a
Source dataset
uspto-grants-1998_12
Patent number
US05849788

Reaction notes

Loading…