HCID 10660125, compound → HCID 10563475, compound

HRID 1457944Notes

Reaction equation

HRID 1457944 reaction equation
[CH2:1]([C:3]1[CH:12]=[C:11]([Cl:13])[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6])[CH3:2]>CO.[OH-].[Na+]>[CH2:1]([C:3]1[CH:12]=[C:11]([Cl:13])[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][C:4]=1[C:5]([OH:7])=[O:6])[CH3:2]

Participants

4

Reactant 1

HCID 10660125HCID 10660125, compound

Product 1

HCID 10563475HCID 10563475, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

15 g of methyl 2-ethyl-4-chloro-5-methylsulphonylbenzoate are stirred, at room temperature for 1 h, in 100 ml of methanol and 50 ml of 2N sodium hydroxide solution. The reaction mixture is then concentrated, and 200 ml of ice water are added. After the mixture has been acidified with conc. HCl, the resulting precipitate is filtered off with suction, washed with ether and dried. 2-Ethyl-4-chloro-5-methylsulphonylbenzoic acid is obtained, m.p. 180°-183°.

Workup

  1. concentrationThe reaction mixture is then concentrated
  2. addition200 ml of ice water are added
  3. filtrationthe resulting precipitate is filtered off with suction
  4. washwashed with ether
  5. customdried

Sources & evidence

ORD record
ord-d8bd8110d26c4322a5ace8553cce03fd
Source dataset
uspto-grants-1998_12
Patent number
US05849796

Reaction notes

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