HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-methyl-2-pyrrolidone → 2-Methyl-4-cyano-5-methylsulphonylbenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 4-chloro-2-methyl-5-(methylsulfonyl)Benzoic acid | HCID 10824478 | — |
| Reactant | HCID 178418546 | HCID 178418546 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Methyl-4-cyano-5-methylsulphonylbenzoic acid | HCID 10561966 | — |
Reaction Steps
8.3 g of 2-methyl-4-chloro-5-methylsulphonylbenzoic acid are mixed together with 70 ml of N-methylpyrrolidone and 7.4 g of CuCN, and the whole is stirred at 150° for 3 days. The reaction mixture is then poured into 250 ml of water and working-up takes place in the customary manner. After recrystallization from methanol, 2-methyl-4-cyano-5-methylsulphonylbenzoic acid is obtained, m.p. 248°-249°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05849796 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-6c22d5399c61463fb184929e720cdd30 |
| Source note | uspto-grants-1998_12 |