HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Toluenesulfonyl chloride → 1,5-Diazabicyclo(4.3.0)non-5-ene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | 2,6-Lutidine | HCID 7937 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 1,5-Diazabicyclo(4.3.0)non-5-ene | HCID 76349 | — |
| Product | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
Reaction Steps
This compound is converted into sulfonate by allowing it to react with methanesulfonyl chloride or p-toluenesulfonyl chloride using triethylamine, pyridine or the like base as an acid-removing agent, and the resulting compound is then allowed to react with pyridine, 2,6-lutidine or the like aromatic heterocyclic compound or 1,8-diazabicyclo[5.4.0]undec-7-ene, 1,5-diazabicyclo[4.3.0]non-5-ene or the like organic base to give ethyl 1-tert-butoxycarbonylaminocyclobutanepropenoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05849757 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-9428948651b340cf9b97831b0e57e9e8 |
| Source note | uspto-grants-1998_12 |