HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Tert-butoxycarbonyl-3-benzyloxycarbonyl-3-azabicyclo[3.2.0]heptane → 1-Tert-butoxycarbonyl-3-azabicyclo[3.2.0]heptane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Tert-butoxycarbonyl-3-benzyloxycarbonyl-3-azabicyclo[3.2.0]heptane | HCID 22100528 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | HCID 178502593 | HCID 178502593 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Tert-butoxycarbonyl-3-azabicyclo[3.2.0]heptane | HCID 22100521 | 136.5% |
Reaction Steps
To a solution of 368 mg (1.02 mmol) of 1-tert-butoxycarbonyl-3-benzyloxycarbonyl-3-azabicyclo[3.2.0]heptane in methanol (20 ml) was added 400 mg of 20% palladium hydroxide-carbon, followed by vigorous stirring in an atmosphere of hydrogen gas. After removing insoluble material by filtration through celite, the resulting filtrate was concentrated to give 274.6 mg of the title compound as a crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05849757 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-40870744f1c0487191a012b7498f00be |
| Source note | uspto-grants-1998_12 |