Benzyl chloroformate → HCID 53928292, compound

Participants

Reaction Steps

A 12 g (45.9 mmol) portion of (3R)-ethyl 1-[(R)-1-phenylethyl]pyrrolidine-3-acetate known in literatures was dissolved in 100 ml of dichloromethane to which was subsequently added dropwise 7.87 ml (55.1 mmol) of benzyl chloroformate at room temperature. After completion of the dropwise addition, the mixture was stirred for 16 hours at the same temperature. After completion of the reaction, the reaction mixture was concentrated. Thereafter, the resulting residue was applied to a silica gel column chromatography to yield 10.1 g (76%) of the title compound as an oily substance from the eluate of n-hexane:ethyl acetate=5:1.

Provenance & Evidence