Sodium Hydroxide → HCID 53788865, compound

Participants

Reaction Steps

A 5.26 g (16.6 mmol) portion of ethyl 1-(1-benzyloxycarbonyl-3-(R)-pyrrolidinyl)cyclopropanecarboxylate was dissolved in 300 ml of ethanol, and the solution was cooled in an ice bath, mixed with 16.6 ml of 10N sodium hydroxide aqueous solution and then stirred at room temperature for 5 days. After completion of the reaction, ethanol was evaporated, and the remaining water layer was then acidified with hydrochloric acid and extracted with diethyl ether (50 ml×4). The organic layers were combined and dried over magnesium sulfate and then the solvent was evaporated to yield 4.95 g of the title compound quantitatively as an oily substance.

Provenance & Evidence