1,2-Dibromoethane → Ethyl 1-acetylcyclopropane-1-carboxylate

Participants

Reaction Steps

A 204 ml (1.6 mol) portion of ethyl acetoacetate and 138 ml (1.6 mol) of 1,2-dibromoethane were dissolved in 3 liters of N,N-dimethylformamide, and the solution was mixed with 460 g (3.3 mol) of potassium carbonate at room temperature and stirred at the same temperature for 2 days. After completion of the reaction, insoluble material was removed by filtration and then N,N-dimethylformamide was evaporated under a reduced pressure of 50 mmHg. The resulting residue was mixed with 1.5 liters of diethyl ether, washed with water (500 ml×3) and then dried over anhydrous sodium sulfate. By evaporating diethyl ether, 113.43 g (45%) of the title compound was obtained as an oily substance.

Provenance & Evidence