Water → HCID 54139749, compound

Participants

Reaction Steps

A 70.21 g (257 mmol) portion of ethyl 1-tert-butoxycarbonylamino-β-oxocyclobutanepropanoate was dissolved in 500.0 ml of ethanol. Thereto was added 4.86 g (514 mmol) of sodium borohydride in small portions under ice cooling. After 2 hours of stirring at the same temperature, water was added and the solvent was evaporated. The resulting residue was extracted with chloroform, washed with saturated brine and then dried over anhydrous sodium sulfate. By evaporating the solvent, 65.25 g (93%) of the title compound was obtained.

Provenance & Evidence