Trifluoroacetic acid → HCID 22100587, compound

Participants

Reaction Steps

To 5.65 g (16.40 mmol) of 1-benzyl-4-(1-tert-butoxycarbonylaminocyclobutyl)-2-pyrrolidone cooled in an ice bath was added dropwise 50.0 ml of trifluoroacetic acid, followed by 1 hour of stirring at room temperature. Excess reagent was evaporated, and the resulting residue was mixed with toluene and subjected to azeotropic heating to yield the title compound quantitatively as a pale yellow oily substance.

Provenance & Evidence