HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-3-(1-tert-butoxycarbonylaminocyclobutyl)pyrrolidine → tert-Butyl (1-(pyrrolidin-3-yl)cyclobutyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-3-(1-tert-butoxycarbonylaminocyclobutyl)pyrrolidine | HCID 22100497 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | tert-Butyl (1-(pyrrolidin-3-yl)cyclobutyl)carbamate | HCID 22100504 | 88% |
Reaction Steps
A 212 mg (0.65 mmol) portion of 1-benzyl-3-(1-tert-butoxycarbonylaminocyclobutyl)pyrrolidine (fr. 1) was dissolved in 20.0 ml of ethanol, mixed with 200 mg of 10% palladium-carbon and stirred for 3 hours under a hydrogen pressure of 4 atm with warming by an infrared lamp. After removing the catalyst by filtration, the solvent was evaporated to yield 136 mg (88%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05849757 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-915f1b3b18774d4780febebddef1a7c8 |
| Source note | uspto-grants-1998_12 |