反应详情

To 13.43 g (38.33 mmol) of diethyl (1-benzyloxycarbonyl-3-azetidinyl)malonate dissolved in 130 ml of ethanol was added 38.44 ml of 1N potassium hydroxide ethanol solution, followed by overnight stirring at room temperature. After evaporation of the solvent, the resulting residue was mixed with 10% citric acid aqueous solution, extracted with chloroform (200 ml×3) and then dried over anhydrous sodium sulfate. By evaporating the solvent, quantitative amount of the title compound was obtained.

1. customAfter evaporation of the solvent
2. additionthe resulting residue was mixed with 10% citric acid aqueous solution
3. extractionextracted with chloroform (200 ml×3)
4. dry with materialdried over anhydrous sodium sulfate
5. customBy evaporating the solvent, quantitative amount of the title compound
6. customwas obtained