反应详情

To 2.68 g (8.83 mmol) of ethyl 1-(1-benzyloxycarbonyl-3-azetidinyl)cyclopropanecarboxylate dissolved in 27 ml of ethanol was added 27 ml of 1N sodium hydroxide aqueous solution, followed by overnight stirring at room temperature. After evaporation of the solvent, the resulting residue was mixed with 10% citric acid aqueous solution, extracted with chloroform (50 ml×3) and then dried over anhydrous sodium sulfate. By evaporating the solvent, 2.35 g (97%) of the title compound was obtained.

1. customAfter evaporation of the solvent
2. additionthe resulting residue was mixed with 10% citric acid aqueous solution
3. extractionextracted with chloroform (50 ml×3)
4. dry with materialdried over anhydrous sodium sulfate
5. customBy evaporating the solvent