Methyl iodide → HCID 18630005, compound

HRID 1458085Notes

Reaction equation

HRID 1458085 reaction equation
[CH2:1]([N:3]([CH2:16][O:17][CH3:18])[C:4](=[O:15])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Si:11]([CH3:14])([CH3:13])[CH3:12])[CH3:2].[CH3:19]I>>[CH2:1]([N:3]([CH2:16][O:17][CH3:18])[C:4](=[O:15])[C:5]1[C:6]([Si:11]([CH3:13])([CH3:12])[CH3:14])=[CH:7][CH:8]=[CH:9][C:10]=1[CH3:19])[CH3:2]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 18630303HCID 18630303, compound

Product 1

HCID 18630005HCID 18630005, compound

Procedure

The compound of Example 50 (1.33 g, 5.0 mmol) and MeI (2.8 g, 20 mmol) were combined according to General Method B. The resulting reaction was partitioned between ethyl acetate and sat aq NaHCO3. The organic phase was washed with brine, dried (MgSO4), and concentrated to afford a quantitative yield of the title compound as an oil.

Workup

  1. customThe resulting reaction
  2. customwas partitioned between ethyl acetate
  3. washThe organic phase was washed with brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-e1b601c3216247a2932ac9cf071b331f
Source dataset
uspto-grants-1998_12
Patent number
US05849723

Reaction notes

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